Ultrasound: A Chemotherapy Sensitizer

Oxygen-Carbon Nanotubes as a Chemotherapy Sensitizer for Paclitaxel in Breast Cancer Treatment

OBJECTIVE To study the in vivo and in vitro effects of adding oxygen carbon nanotubes (CNTs) to chemotherapy for breast cancer. METHODS MCF-7 and SK-BR-3 breast cancer cells were co-cultured with paclitaxel and then exposed to oxygen-CNTs under hypoxic conditions. Cell proliferation, viability, and apoptosis rate were analyzed. Hypoxia-inducible factor-1 alpha (HIF-1α) expression was measured...

A new sensitizer DVDMS combined with multiple focused ultrasound treatments: an effective antitumor strategy.

Sonodynamic therapy (SDT) was developed as a promising noninvasive approach. The present study investigated the antitumor effect of a new sensitizer (sinoporphyrin sodium, referred to as DVDMS) combined with multiple ultrasound treatments on sarcoma 180 both in vitro and in vivo. The combined treatment significantly suppressed cell viability, potentiated apoptosis, and markedly inhibited angiog...

What makes a chemical a respiratory sensitizer?

PURPOSE OF REVIEW In this article we consider the characteristics that are associated with chemical respiratory allergens, and that may be essential for effective sensitization of the respiratory tract. RECENT FINDINGS Chemical respiratory allergens share some characteristics with other chemical allergens, specifically chemical allergens that cause skin sensitization and allergic contact derm...

CPSC Staff’s Strong Sensitizer Guidance Document For a product containing a strong sensitizer

For a product containing a strong sensitizer to be considered a hazardous substance and to require cautionary labeling under the FHSA, the product must be capable of causing substantial personal injury or substantial illness during, or as a result of, customary or reasonably foreseeable handling or use, including reasonably foreseeable ingestion by children. This requires consideration of the r...

Low toxicity radiation sensitizer